Josh Gordon made his debut with the Patriots, hauling in his first reception in the middle of the first quarter. He finished with two catches for 32 yards.
Cordarrelle Patterson became the 70th different player to catch a touchdown pass from Tom Brady.
Tom Brady was 23-of-35 for 274 yards, three touchdowns and two interceptions, while Ryan Tannehill was just 11-of-20 for 100 yards and one interception. Brock Osweiler took over for Tannehill in the fourth quarter and went 4-of-5 for 35 yards and one touchdown.
Sony Michel led the way for the Patriots' rushing efforts with 25 carries, 112 yards and one touchdown. James White had eight carries for 44 yards and one score on the ground.
Miami's rushing efforts were led by Frank Gore who ran the ball 11 times for 41 yards.
White also led the Patriots receivers with eight catches, 68 yards and another score through the air. Phillip Dorsett added 55 receiving yards, while Cordarrelle Patterson had 54.
For the Dolphins, it was Kenny Stills who led the way for the receivers. Stills had three receptions for 40 yards, while Gore added two catches for 16 yards and one touchdown.
New England's defense was led by Jonathan Jones who tallied eight total tackles, including five solo. John Simon and Adam Butler each posted a sack apiece.
For Miami, Kiko Alonso posted 12 total tackles, including three solo, while Jerome Baker and Minkah Fitzpatrick each posted ten total tackles apiece.
JC Jackson had an interception for the Patriots, while Bobby McCain and Minkah Fitzpatrick had one each for the Dolphins.
New England will travel to Miami on Sunday, Dec. 9, 2018. The Patriots-Dolphins matchup is set for 1pm from Hard Rock Stadium.